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[Targeted Drug Therapy for Intracranial Tumors]

Han Wang1,2, Yue-Long Wang1, Zhi-Yong Liu1

  • 1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|July 24, 2022
PubMed

Insights

Targeted drug therapy for intracranial tumors faces challenges due to the blood-brain barrier. Overcoming this barrier is crucial for effective precision medicine in treating brain tumors.

Area of Science:

  • Neuro-oncology
  • Precision Medicine
  • Molecular Biology
  • Genomics

Background:

  • Intracranial tumors significantly impact human health, necessitating individualized treatment strategies.
  • Targeted drug therapy, a key component of precision medicine, is a major research focus for brain tumors.
  • Advances in molecular biology and genomics offer potential therapeutic targets for intracranial tumors.

Purpose of the Study:

  • To review the current landscape of targeted drug therapies for various intracranial tumors.
  • To discuss the efficacy of existing targeted drug treatments for brain tumors.
  • To identify challenges and propose future perspectives for intracranial tumor treatment.

Main Methods:

  • Literature review of current targeted drug therapies for intracranial tumors.
  • Analysis of treatment efficacy based on tumor type and drug delivery methods.
  • Discussion of the impact of biological barriers on drug concentration.

Main Results:

  • Precision medicine approaches are being developed for intracranial tumors.
  • The blood-brain barrier and blood-tumor barrier impede drug delivery to brain targets.
  • Elevating intracranial drug concentration is a critical challenge for current therapies.

Conclusions:

  • Targeted drug therapy holds promise for treating intracranial tumors.
  • Overcoming drug delivery barriers is essential for successful precision treatment.
  • Further research is needed to enhance drug concentration at intracranial targets for improved patient outcomes.
Keywords:
CraniopharyngiomaGliomaMeningiomaPituitary adenomaSchwannomaTargeted drug therapy

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