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Published on: May 30, 2025
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Antisense long non-coding RNAs in gastric cancer
Yong-Qiang Gong1, Tai-Liang Lu1, Fu-Tao Hou1
1Department of Gastrointestinal Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.
Summary
This review explores antisense long non-coding RNAs (lncRNAs) in gastric cancer, highlighting their role alongside Helicobacter pylori infection and epigenetics. These lncRNAs offer potential for early diagnosis and novel therapeutic strategies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Gastric cancer presents a significant global health challenge with high mortality and regional incidence variations.
- Helicobacter pylori infection and epigenetic modifications are key factors in gastric cancer development.
- Antisense long non-coding RNAs (lncRNAs) are increasingly recognized for their involvement in gastric cancer's biological and functional aspects.
Purpose of the Study:
- To review predisposing factors and the interplay between H. pylori and epigenetics in gastric cancer.
- To compile and discuss diverse antisense lncRNAs implicated in gastric cancer.
- To elucidate the molecular mechanisms and regulatory roles of individual antisense lncRNAs in gastric cancer.
Main Methods:
- Literature review and synthesis of existing research on antisense lncRNAs in gastric cancer.
- Analysis of the interaction between H. pylori, epigenetics, and lncRNA expression.
- Examination of molecular mechanisms underlying antisense lncRNA function in gastric cancer.
Main Results:
- Identified and summarized various antisense lncRNAs associated with gastric cancer.
- Detailed the complex interactions between H. pylori, epigenetic changes, and antisense lncRNA expression.
- Provided insights into the specific molecular roles of different antisense lncRNAs in cancer progression.
Conclusions:
- Antisense lncRNAs play a crucial role in the pathogenesis of gastric cancer.
- Understanding these lncRNAs can lead to improved diagnostic markers and therapeutic targets.
- This review offers a comprehensive overview and future directions for research on antisense lncRNAs in gastric cancer treatment.
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