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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Psoriasis treatment using Indigo Naturalis: Progress and strategy.

Qianhui Zhang1, Jin Xie1, Gefei Li1

  • 1State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China.

Journal of Ethnopharmacology
|July 25, 2022
PubMed
Summary

Indigo Naturalis, a Traditional Chinese Medicine, shows potential for treating psoriasis by regulating immune responses and cell differentiation. Further research is needed to confirm its therapeutic efficacy and mechanisms.

Keywords:
Chemical componentsClinical applicationIndigo naturalisMechanism of actionPsoriasisTraditional medicinal applications

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Area of Science:

  • Pharmacology
  • Dermatology
  • Traditional Chinese Medicine

Background:

  • Psoriasis is a prevalent public health concern with no definitive cure.
  • Traditional Chinese Medicine (TCM) offers potential alternative therapies for psoriasis.
  • Indigo Naturalis is a recognized TCM with historical use in treating psoriasis.

Purpose of the Study:

  • To review recent advancements in using Indigo Naturalis for psoriasis treatment.
  • To elucidate the mechanisms of action and application strategies of Indigo Naturalis in managing psoriasis.
  • To explore various preparations of Indigo Naturalis for psoriasis therapy.

Main Methods:

  • Comprehensive literature search across multiple online databases including PubMed, Web of Science, and Google Scholar.
  • Information gathering on Indigo Naturalis from scientific and patent databases.
  • Review of ethnopharmacological relevance, mechanisms, and clinical applications.

Main Results:

  • Indigo Naturalis exerts therapeutic effects on psoriasis by modulating immune cells and signaling pathways.
  • Key mechanisms include regulating keratinocyte proliferation and differentiation.
  • It also impacts inflammatory infiltration and microvascular changes in skin lesions.

Conclusions:

  • Indigo Naturalis demonstrates a multi-component, multi-target, and multi-pathway therapeutic approach characteristic of TCM.
  • Current research methodologies have limitations, impacting result interpretation.
  • Further rigorous research is essential to validate the therapeutic potential of Indigo Naturalis for psoriasis.