Related Experiment Video
Updated: Sep 3, 2025
Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy
Published on: May 3, 2019
Apparent diffusion coefficient histogram analysis to preoperative evaluate intracranial solitary fibrous tumor:
Haiting Yang1, Xianwang Liu1, Jian Jiang1
1Department of Radiology, Lanzhou University Second Hospital, Cuiyingmen No.82, Chengguan District, Lanzhou 730030, People's Republic of China; Second Clinical School, Lanzhou University, Lanzhou, People's Republic of China; Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, People's Republic of China; Gansu International Scientific and Technological Cooperation Base of Medical Imaging Artificial Intelligence, Lanzhou, People's Republic of China.
Purpose:
To explore the value of apparent diffusion coefficient (ADC) histogram analysis in preoperative evaluating intracranial solitary fibrous tumor (SFT) and further investigate the relationship between ADC histogram parameters and the Ki-67 proliferation index.
Methods:
From January 2014 to March 2022, 37 patients with intracranial SFT (grade 2, n = 20; grade 3, n = 17) who underwent preoperative diffusion-weighted imaging were enrolled in this study. For each tumor, nine histogram parameters were automatically extracted and selected using MaZda software based on the axial ADC maps of the whole tumor, including mean, variance, skewness, kurtosis, as well as the 1st, 10th, 50th, 90th, and 99th percentile ADC (Perc.01, Perc.10, Perc.50, Perc.90, Perc.99). Differences in ADC histogram parameters between grade 2 and 3 intracranial SFT were compared. Receiver operating characteristic (ROC) curves were drawn to determine the diagnostic performance, and Pearson's correlation coefficient was used to investigate the relationship between these parameters and the Ki-67 proliferation index.
Results:
The mean, Perc.01, Perc.10, Perc.50, Perc.90, and Perc.99 were significantly lower in grade 3 than in grade 2 intracranial SFT (all P < 0.05). ROC analysis showed that these parameters can effectively distinguish between the two groups, with Perc.01 generating the best differentiation performance. Significant negative correlations were also observed between these parameters and the Ki-67 proliferation index (r = -0.436 ~ -0.522, all P < 0.05). However, there was no significant difference in variance, skewness, or kurtosis between the two groups (all P > 0.05).
Conclusions:
ADC histogram analysis enables effective preoperative distinction of grade 2 and grade 3 intracranial SFT.
