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Published on: September 25, 2019
The value of diffusion weighted imaging in predicting the clinical progression of perforator artery cerebral
Wenjing Yu1, Jiajia Yang1, Lulu Liu2
1The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Objectives:
To investigate the value of diffusion weighted imaging (DWI) in predicting the clinical progression of perforator artery cerebral infarction.
Methods:
The magnetic resonance imaging (MRI) data of patients with perforator artery cerebral infarction hospitalized in our hospital from October 2015 to February 2022 were analyzed retrospectively. Then we compared the differences of apparent diffusion coefficient (ADC) value, maximal size, location of cerebral infarction, clinical data and treatment plan between the two groups.
Results:
A total of 81 patients with perforating artery cerebral infarction were included, with 33 patients in the progressive cerebral infarction (PCI) group and 48 patients in the non-progressive cerebral infarction (NPCI) group. The ADC value in the progressive group was lower than that in the non-progressive group (P < 0.001), and ADC value was an independent factor influencing the clinical progression (OR = 0.974, 95 %CI = 0.960-0.989, P = 0.001); The average area of cerebral infarction in the progressive group was larger than that in the non-progressive group (P = 0.004). There was no difference between the two groups (P > 0.05) in terms of clinical data and treatment plan.
Conclusions:
The ADC value and maximal size of infarction were correlated with the clinical Progression. ADC value was an independent factor influencing the clinical progression of perforating artery cerebral infarction, which could be used for the prediction of clinical progress and provide guidance for the development of individualized treatment.
Insights
Diffusion weighted imaging (DWI) helps predict perforator artery cerebral infarction progression. Lower apparent diffusion coefficient (ADC) values and larger infarct size indicate a higher risk of clinical progression.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Perforator artery cerebral infarction (PACI) is a common type of stroke.
- Predicting clinical progression in PACI is crucial for timely intervention.
- Diffusion weighted imaging (DWI) offers insights into tissue microstructure.
Purpose of the Study:
- To evaluate the predictive value of DWI, specifically apparent diffusion coefficient (ADC) values, for the clinical progression of PACI.
- To identify imaging biomarkers associated with PACI progression.
Main Methods:
- Retrospective analysis of MRI data from 81 PACI patients.
- Comparison of ADC values, infarct size, and clinical data between progressive (PCI) and non-progressive (NPCI) groups.
- Statistical analysis to determine independent predictors of clinical progression.
Main Results:
- Patients with progressive PACI had significantly lower ADC values compared to non-progressive cases (P < 0.001).
- ADC value was identified as an independent predictor of clinical progression (OR = 0.974, P = 0.001).
- Larger average infarct size was observed in the progressive group (P = 0.004).
Conclusions:
- ADC value derived from DWI is a valuable independent predictor of clinical progression in PACI.
- Maximal infarct size also correlates with clinical progression.
- These imaging findings can guide individualized treatment strategies for PACI patients.
