Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cleavage and Blastulation01:33

Cleavage and Blastulation

45.6K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
45.6K
Fertilization01:38

Fertilization

71.9K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
71.9K
In Vitro Fertilization01:24

In Vitro Fertilization

379
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
379

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel endometrial receptivity test increases clinical pregnancy and live birth rates in patients with recurrent implantation failure: Secondary analysis of a prospective clinical trial.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2025
Same author

The density of the inner cell mass is a new indicator of the quality of a human blastocyst: a valid supplement to the Gardner scoring system.

Human reproduction (Oxford, England)·2024
Same author

Multiple collapses of blastocysts after full blastocyst formation is an independent risk factor for aneuploidy - a study based on AI and manual validation.

Reproductive biology and endocrinology : RB&E·2024
Same author

Cumulative live birth rate and neonatal outcomes after early rescue ICSI: a propensity score matching analysis.

Human reproduction open·2023
Same author

Application of artificial intelligence in gametes and embryos selection.

Human fertility (Cambridge, England)·2023
Same author

An artificial intelligence model (euploid prediction algorithm) can predict embryo ploidy status based on time-lapse data.

Reproductive biology and endocrinology : RB&E·2021

Related Experiment Video

Updated: Sep 3, 2025

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality
08:06

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

Published on: October 18, 2024

509

Faster Fertilization and Cleavage Kinetics Reflect Competence to Achieve a Live Birth: Data from Single-Embryo

Yongle Yang1, Xiyuan Dong1, Jian Bai1

  • 1Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Biomed Research International
|July 25, 2022
PubMed
Summary

Early embryo development speed predicts live birth success, particularly for women aged 26-36. This finding is most pronounced with 8-21 retrieved oocytes, offering insights for embryo selection strategies.

More Related Videos

Human Blastocyst Biopsy and Vitrification
10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

22.7K
Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model
07:02

Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model

Published on: May 16, 2019

12.8K

Related Experiment Videos

Last Updated: Sep 3, 2025

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality
08:06

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

Published on: October 18, 2024

509
Human Blastocyst Biopsy and Vitrification
10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

22.7K
Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model
07:02

Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model

Published on: May 16, 2019

12.8K

Area of Science:

  • Reproductive Medicine and Embryology
  • Assisted Reproductive Technologies (ART)
  • Developmental Biology

Background:

  • Live birth rates in assisted reproductive technologies are influenced by numerous factors.
  • Embryo developmental kinetics, or the timing of early cell divisions, is a critical parameter.
  • Understanding how maternal age and oocyte yield affect developmental kinetics is crucial for optimizing outcomes.

Purpose of the Study:

  • To evaluate the correlation between early embryonic developmental kinetics and the probability of achieving a live birth (LB).
  • To investigate the influence of maternal age and the quantity of retrieved oocytes on this relationship.
  • To identify optimal embryo selection criteria based on morphokinetic parameters for enhanced live birth rates.

Main Methods:

  • Retrospective cohort study involving 3,021 single-embryo transfer cycles.
  • Analysis of live birth (LB) and non-live birth (NLB) outcomes correlated with detailed morphokinetic data.
  • Stratification of patients by age groups (20-25, 26-30, 31-36, ≥37 years) and oocyte yield (≤7, 8-14, 15-21, ≥22).

Main Results:

  • Embryos achieving LB demonstrated significantly faster early developmental kinetics compared to NLB embryos.
  • This kinetic difference was less pronounced in the youngest (20-25 years) and oldest (≥37 years) maternal age groups.
  • The distinction in kinetics between LB and NLB embryos was also less evident with very low (≤7) or very high (≥22) oocyte yields.

Conclusions:

  • Early embryonic morphokinetic parameters serve as valuable indicators for embryo selection strategies to improve live birth rates.
  • The predictive value of morphokinetics is most significant for patients aged 26-36 years with 8-21 retrieved oocytes.
  • Maternal age and oocyte yield can modulate the association between embryonic kinetics and live birth potential.