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Updated: Sep 3, 2025

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
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Metabolic Regulation of Cardiac Regeneration

Xuewen Duan1, Xingguang Liu2, Zhenzhen Zhan1

  • 1Key Laboratory of Arrhythmias of the Ministry of Education of China, Institute of Heart Failure, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Frontiers in Cardiovascular Medicine
|July 25, 2022
PubMed

Insights

Heart disease mortality is high, with ischemic cardiomyopathy causing irreversible cardiomyocyte loss. This review explores how energy metabolism influences heart regeneration, offering potential therapeutic strategies for heart repair.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Ischemic cardiomyopathy leads to irreversible cardiomyocyte loss, impaired contractility, and heart failure.
  • Adult mammalian hearts have limited regenerative capacity due to cardiomyocyte cell cycle exit.
  • Neonatal hearts show greater regenerative potential, highlighting a window for therapeutic intervention.

Purpose of the Study:

  • To review the role of energy metabolism in cardiac regeneration.
  • To elucidate how metabolites regulate gene expression and epigenetic patterns affecting heart repair.
  • To identify strategies for manipulating myocardial energy metabolism to promote heart regeneration.

Main Methods:

  • Literature review focusing on myocardial energy metabolism and cardiac regeneration.
  • Analysis of studies on glucose, fatty acid, and amino acid metabolism in cardiac physiology and pathology.
  • Synthesis of current knowledge on metabolite-mediated regulation of gene expression and epigenetics in the heart.

Main Results:

  • Mitochondrial metabolism is crucial for cardiac function and failure compensation.
  • Metabolites act as key regulators of gene expression and epigenetic patterns.
  • The precise role of myocardial energy metabolism during heart regeneration remains largely undefined.

Conclusions:

  • Understanding myocardial energy metabolism is essential for promoting endogenous cardiomyocyte regeneration.
  • Targeting metabolic pathways may offer novel therapeutic strategies for heart repair after injury.
  • Further research into metabolic regulation of heart regeneration is critical for improving patient outcomes.

Keywords:
amino acid metabolismcardiomyocyte proliferationfatty acid metabolismglucose metabolismheart regenerationmetabolism regulation

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