Related Experiment Video
Updated: Sep 3, 2025
Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
Published on: September 8, 2023
Vaccination Is Associated With Shorter Time to Target Cycle Threshold Value in Patients With SARS-CoV-2 Omicron
Jiajun Wu1, Yong Wei1, Feng Shen1
1Department of COVID-19 for Temporary Centralized Isolation and Treatment, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background:
Limited data are available on the responses to vaccination for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant in the Chinese population. This study aimed to investigate whether vaccination could alter the disease course of SARS-CoV-2 Omicron variant.
Methods:
A retrospective cohort included 142 patients who had no or mild symptoms and were admitted to our department for centralized isolation after being locally infected with SARS-CoV-2 Omicron variant from March 4 to 30, 2022, in Shanghai, China.
Results:
Of the 142 subjects with the mean age of 43.1 years, 53.5% were male and 90.8% had been vaccinated before the infection. Comparing the vaccinated with the unvaccinated patients, there was no difference in patient characteristics, but patients with vaccination had shorter time to target cycle threshold value (TtCT) (vaccinated vs. unvaccinated, 12.6 ± 3.4 vs. 14.8 ± 4.7 days, P = 0.039). There was no difference in TtCT between heterogeneous and homologous vaccination. Of subjects with homologous vaccination, 43.1% were vaccinated with CoronaVac (Sinovac Life Science), 47.2% with Sinopharm BBIBP-CorV, 4.9% with Sinopharm WIBP, 3.3% with CanSinoBio, and 1.6% with Zhifei Longcom. No difference in TtCT was observed among different vaccines. Comparing two-dose primary vaccination with three-dose booster vaccination, we found no difference in TtCT either.
Conclusion:
Vaccination is associated with shorter TtCT in patients with SARS-CoV-2 Omicron variant.
Insights
COVID-19 vaccination shortened the time to target cycle threshold (TtCT) in patients infected with the SARS-CoV-2 Omicron variant. This finding suggests vaccination may influence the disease course of Omicron infections in China.
Area of Science:
- Virology
- Immunology
- Public Health
Background:
- Limited data exist on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant vaccine responses in China.
- The Omicron variant has become globally dominant, necessitating understanding its interaction with vaccination.
Purpose of the Study:
- To investigate the impact of vaccination on the disease course of SARS-CoV-2 Omicron variant infections.
- To analyze whether vaccination status alters key clinical indicators in Omicron-infected individuals.
Main Methods:
- A retrospective cohort study of 142 patients with mild or no symptoms of SARS-CoV-2 Omicron variant infection in Shanghai, China.
- Analysis of patient characteristics and time to target cycle threshold value (TtCT) between vaccinated and unvaccinated groups.
Main Results:
- 90.8% of patients were vaccinated prior to Omicron infection.
- Vaccinated patients demonstrated a significantly shorter time to target cycle threshold value (TtCT) compared to unvaccinated patients (12.6 vs. 14.8 days, P=0.039).
- No significant differences in TtCT were observed based on vaccine type (heterologous vs. homologous) or number of doses (two vs. three).
Conclusions:
- Vaccination is associated with a shorter time to target cycle threshold value (TtCT) in patients infected with the SARS-CoV-2 Omicron variant.
- These findings suggest a potential benefit of vaccination in modulating the early course of Omicron infections.
Related Concept Videos
01:51Vaccinations
01:15Drug Concentration Versus Time Correlation
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...
01:23Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
01:20Desensitization and Tachyphylaxis