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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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Ticagrelor use in patients after percutaneous coronary intervention: one year follow up in a community hospital

Sarath Lal Mannumbeth Renjithlal1, Mohamed Magdi1, Keerthi Renjith2

  • 1Internal Medicine Residency Program, Unity Hospital, Rochester Regional Health Rochester, NY, USA.

American Journal of Cardiovascular Disease
|July 25, 2022
PubMed

Insights

Ticagrelor use post-PCI was completed by 65% of patients. Common reasons for stopping ticagrelor include dyspnea and high medication costs, impacting acute coronary syndrome treatment.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • American College of Cardiology guidelines recommend ticagrelor over clopidogrel for acute coronary syndrome (ACS).
  • A clinical observation revealed frequent switching from ticagrelor to clopidogrel post-percutaneous coronary intervention (PCI).

Purpose of the Study:

  • To evaluate the utilization rate of ticagrelor in patients undergoing PCI.
  • To identify and categorize the reasons for ticagrelor non-use or discontinuation.

Main Methods:

  • Retrospective data analysis of 277 patients who underwent PCI for ACS at Unity Hospital of Rochester (January 2019 - January 2020).

Main Results:

  • 65% (179 patients) completed one year of ticagrelor therapy.
  • 35% (98 patients) switched to clopidogrel.
  • Dyspnea (42 patients) and medication cost (41 patients) were the primary reasons for switching from ticagrelor.

Conclusions:

  • Ticagrelor completion rates at one year post-PCI were 65% in this community hospital setting.
  • Adverse events like dyspnea and financial burden significantly contribute to ticagrelor discontinuation.
Abstract

Keywords:
Ticagreloracute coronary syndromeclopidogreldual antiplatelet therapymedication compliance/adherencepercutaneous coronary intervention

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