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Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

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Published on: October 15, 2010

Endothelial function evaluation in idiopathic vs. ischemic dilated cardiomyopathy.

Edoardo Pancaldi¹, Chiara Tedino¹, Mauro Riccardi¹

¹Cardiology Unit, Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia Brescia, Italy.

American Journal of Cardiovascular Disease

|July 25, 2022

Summary

Endothelial dysfunction (ED) is similarly prevalent in patients with idiopathic dilated cardiomyopathy (IDCM) and ischemic cardiomyopathy (ICM). Peripheral arterial tonometry reveals compromised endothelial function in both heart failure types.

Keywords:

EndoPAT HF dilated cardiomyopathy endothelial dysfunction ischemic cardiomyopathy

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Published on: October 22, 2014

Area of Science:

Cardiology
Vascular Biology
Heart Failure Pathophysiology

Background:

Endothelial dysfunction (ED) is increasingly recognized in early heart failure (HF) pathogenesis.
The role of ED in HF versus atherosclerosis in ischemic cardiomyopathy (ICM) requires clarification.

Purpose of the Study:

To compare the prevalence of ED in idiopathic dilated cardiomyopathy (IDCM) versus ICM.
To investigate endothelial function in distinct heart failure etiologies.

Main Methods:

Observational study including 107 patients (65 IDCM, 42 ICM).
Endothelial function assessed using peripheral arterial tonometry (EndoPAT) to calculate the Reactive Hyperaemia Index (RHI).
ED defined as RHI ≤1.67; normal function >2.00.

Main Results:

Similar prevalence of ED (RHI ≤1.67 and RHI ≤2.00) in both IDCM and ICM groups.
Differences observed in sex distribution, dyslipidemia, and statin use between groups.

Conclusions:

Endothelial function appears equally compromised in IDCM and ICM.
Peripheral artery tonometry is a valuable tool for assessing endothelial function in heart failure.