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Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
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Clinical Profile of Monomicrobial Corynebacterium Hip and Knee Periprosthetic Joint Infections

Hussam Tabaja1, Don Bambino Geno Tai1, Elena Beam1

  • 1Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Open Forum Infectious Diseases
|July 25, 2022
PubMed
Abstract

Insights

Monomicrobial Corynebacterium periprosthetic joint infection (PJI) is challenging to treat. Vancomycin and linezolid are effective, while debridement and implant retention (DAIR) may be suitable for acute cases.

Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Microbiology

Background:

  • Corynebacterium periprosthetic joint infection (PJI) is an under-described infectious syndrome.
  • Previous studies often included polymicrobial infections, obscuring Corynebacterium-specific characteristics.
  • This study focuses on monomicrobial Corynebacterium PJI cases.

Purpose of the Study:

  • To describe the clinical features of monomicrobial Corynebacterium PJI.
  • To evaluate management strategies and patient outcomes.
  • To identify effective antimicrobial and surgical treatments.

Main Methods:

  • Retrospective query of the Mayo Clinic Total Joint Registry.
  • Inclusion of adult patients with monomicrobial Corynebacterium knee or hip PJI (2010-2019).
  • Analysis of clinical data, microbial species, antimicrobial susceptibility, and treatment outcomes.

Main Results:

  • 20 cases (1%) of monomicrobial Corynebacterium PJI were identified.
  • Most patients were male (55%), median age 64, with 70% experiencing chronic symptoms (>4 weeks).
  • 90% of PJIs were late (>3 months postimplantation), predominantly C. striatum (70%). Vancomycin and linezolid showed 100% susceptibility; daptomycin was effective in 75%.

Conclusions:

  • Corynebacterium PJIs present therapeutic challenges due to limited antibiotic options and unclear surgical management.
  • Vancomycin and linezolid are the most reliable antimicrobial agents.
  • Debridement and implant retention (DAIR) might be considered for acute PJI, but long-term suppression strategies require further investigation.
Keywords:
Corynebacterium amycolatumCorynebacterium jeikeiumCorynebacterium speciesCorynebacterium striatumperiprosthetic joint infection

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