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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Transient directing group enabled Pd-catalyzed C-H oxygenation of benzaldehydes and benzylic amines
Mixiang Tian1, Lidong Shao1, Xiaosan Su1
1Center for Scientific Research, Yunnan University of Chinese Medicine Kunming Yunnan 650500 P. R. China wangjunliangedu@163.com sunruifen@ynutcm.edu.cn.
Abstract:
We report a general protocol for ortho-C-H fluoroalkoxylation of benzaldehydes and benzylic amines utilizing an inexpensive amino amide as a transient directing group. In the presence of an electrophilic fluorinating bystanding oxidant and fluorinated alcohols, a wide range of benzaldehydes and benzylic amines could be oxygenated selectively at the ortho positions to afford fluoroalkyl aryl ethers. This elegant approach would provide appealing strategies for synthesis of drug molecules and natural products.
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