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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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Identifying an Immune-Related Gene ST8SIA1 as a Novel Target in Patients With Clear-Cell Renal Cell Carcinoma

Xu Hu1, Yanfei Yang2, Yaohui Wang1

  • 1Institute of Urology, Department of Urology, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.

Frontiers in Pharmacology
|July 25, 2022
PubMed

Insights

This study identifies ST8SIA1 as a novel immune-related biomarker for clear-cell renal cell carcinoma (ccRCC). Elevated ST8SIA1 expression correlates with advanced stages and poorer outcomes in ccRCC patients.

Area of Science:

  • Oncology
  • Immunology
  • Genetics

Background:

  • Clear-cell renal cell carcinoma (ccRCC) is a prevalent urological cancer.
  • The tumor microenvironment significantly influences ccRCC progression.
  • Identifying novel immune-related biomarkers is crucial for ccRCC management.

Purpose of the Study:

  • To identify novel immune-related biomarkers in ccRCC.
  • To investigate the prognostic value of ST8SIA1 in ccRCC.
  • To explore the association between ST8SIA1 and the tumor immune microenvironment.

Main Methods:

  • Utilized ESTIMATE algorithm on GEO and TCGA databases to identify differentially expressed genes.
  • Performed Kaplan-Meier survival analysis, univariate and multivariate analyses.
  • Explored ST8SIA1's association with immune cells, immune checkpoints, and functional pathways via GSEA and online databases.

Main Results:

  • ST8SIA1 was identified as a potential prognostic gene in ccRCC.
  • Elevated ST8SIA1 mRNA and protein levels were observed in ccRCC tissues, correlating with higher T and TNM stages.
  • Higher ST8SIA1 expression was linked to worse overall survival (OS) and negatively correlated with tumor purity but positively with immune cell infiltration and immune checkpoint genes.

Conclusions:

  • ST8SIA1 is an immune-related gene and a potential prognostic biomarker in ccRCC.
  • ST8SIA1 may serve as a therapeutic target for ccRCC patients.
  • Further research is warranted to validate these findings and explore therapeutic strategies targeting ST8SIA1.
Keywords:
ST8SIA1clear-cell renal cell carcinomaimmune-relatedprognosistarget

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