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Semi-PBPK Modeling and Simulation to Evaluate the Local and Systemic Pharmacokinetics of OC-01(Varenicline) Nasal

Xiaofei Wu1, Fan Zhang1, Mengyang Yu1

  • 1Clinical Pharmacology Research Center, State Key Laboratory of Complex Severe and Rare Diseases, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Frontiers in Pharmacology
|July 25, 2022
PubMed

Keywords:
OC-01dry eye diseasenasal spraypharmacokineticssemi-PBPK modelvarenicline

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