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Related Experiment Video

Updated: Sep 3, 2025

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

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Primary Brainstem Lymphoma: A Population-Based Study.

Junyu Chen1, Bo Cen1, Fei Hu1

  • 1General Hospital of the Yangtze River Shipping, Wuhan Brain Hospital, Wuhan, China.

Frontiers in Surgery
|July 25, 2022
PubMed
Summary
This summary is machine-generated.

Primary brainstem lymphoma (PBSL) is rare. This study identified age, tumor number, and chemotherapy as key factors influencing survival in PBSL patients, highlighting chemotherapy

Keywords:
SEERchemotherapyprimary brainstem lymphomasurgerysurvival

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Area of Science:

  • Neuro-oncology
  • Hematology
  • Epidemiology

Background:

  • Primary brainstem lymphoma (PBSL) is a rare and aggressive malignancy with limited understanding.
  • Characterizing PBSL is crucial for improving patient outcomes.
  • This study provides insights into the clinical features and survival of PBSL.

Purpose of the Study:

  • To characterize the clinical features of primary brainstem lymphoma (PBSL).
  • To estimate the overall survival (OS) and disease-specific survival (DSS) rates for PBSL patients.
  • To identify factors influencing survival in PBSL.

Main Methods:

  • Utilized data from the Surveillance, Epidemiology, and End Results (SEER) program (1975-2016).
  • Included patients with a histological diagnosis of primary lymphoma in the brainstem (C71.7).
  • Employed log-rank tests and Cox proportional hazard analyses to identify survival-related factors.

Main Results:

  • PBSL accounts for 2.7% of brainstem malignancies, with a median age of 59.5 years.
  • Diffuse large B cell lymphoma was the most common subtype (84.5%).
  • Three-year OS and DSS rates were 42.7% and 53.5%, respectively. Age, tumor number, and chemotherapy significantly impacted OS; age and chemotherapy affected DSS.

Conclusions:

  • Survival rates for PBSL patients were estimated.
  • Key prognostic factors for OS and DSS, including age and chemotherapy, were identified.
  • Chemotherapy plays a critical role in the treatment of PBSL patients.