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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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RNA Splicing01:32

RNA Splicing

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Related Experiment Video

Updated: Sep 3, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

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Long non-coding RNA in prostate cancer.

Christine An1, Ian Wang2, Xin Li3

  • 1Institute of Human Nutrition, Columbia University New York, NY, USA.

American Journal of Clinical and Experimental Urology
|July 25, 2022
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) play crucial roles in prostate cancer. This review details key lncRNAs, highlighting their functions as tumor suppressors or oncogenes, offering insights for diagnostics and prognostics.

Keywords:
GAS-007GAS5HOTAIRMALAT1MEG3NEAT1PCA3PCAT1PCAT14PVT1Prostate cancerSChLAP1UCA1lncRNA

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

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Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
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Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

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Related Experiment Videos

Last Updated: Sep 3, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
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Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer is a leading cancer diagnosis in males.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cancer pathogenesis.
  • Dysregulated lncRNA expression impacts tumor proliferation and metastasis, acting as oncogenes or tumor suppressors.

Purpose of the Study:

  • To review current knowledge on prostate cancer-associated lncRNAs.
  • To elucidate the specific mechanisms and functions of lncRNAs in prostate cancer.
  • To identify potential diagnostic and prognostic biomarkers.

Main Methods:

  • Literature review of studies on prostate cancer-related lncRNAs.
  • Analysis of lncRNA functions, including tumor suppression and oncogenesis.
  • Identification of signaling pathways and molecular interactions involving lncRNAs.

Main Results:

  • Key lncRNAs reviewed include GAS5, MEG3, PCAT1, PVT1, and UCA1.
  • GAS5 and MEG3 act as tumor growth inhibitors, interacting with pathways like AKT/MTOR and miR-9-5p.
  • PCAT1, PVT1, and UCA1 promote tumor growth by affecting pathways such as P13K/AKT and regulating genes like PCNA.

Conclusions:

  • Understanding lncRNA roles in prostate cancer is crucial for advancing pathology.
  • Specific lncRNAs demonstrate potential as novel diagnostic and prognostic tools.
  • Further research into lncRNA mechanisms can lead to targeted therapeutic strategies.