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In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
Published on: September 7, 2022
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Aptamer-based biosensors for virus protein detection
Beibei Lou1, Yanfei Liu2, Meilin Shi3
1Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, Hunan Province, PR China.
Trends in Analytical Chemistry : TRAC
|July 25, 2022
Summary
Aptasensors offer a promising approach for rapid virus detection. This review details aptasensor mechanisms and viral targets, aiding in developing effective diagnostic tools, especially for SARS-CoV-2.
Area of Science:
- Biomedical Engineering
- Molecular Diagnostics
- Biosensing Technology
Background:
- Accurate and early virus detection is crucial for effective clinical management and treatment.
- Aptasensors, utilizing aptamers (DNA/RNA), are emerging as sensitive tools for pathogen identification.
- The review focuses on aptasensor applications in virology, with a specific emphasis on SARS-CoV-2 detection.
Purpose of the Study:
- To review and classify aptasensors for virus detection based on viral target proteins.
- To illustrate common detection mechanisms employed in aptasensors.
- To summarize aptamers targeting various viral proteins and analyze their performance.
Main Methods:
- Literature review of recent aptasensor research for virus detection.
- Classification of aptasensors by viral target protein.
- Analysis of detection mechanisms including colorimetry, fluorescence, SPR, SERS, electrochemical methods, and FETs.
Main Results:
- Summarized aptamers against diverse viral target proteins.
- Detailed common aptasensor detection mechanisms and their performance.
- Highlighted the relationship between viral biomarkers and detection method efficacy.
Conclusions:
- Aptasensors provide versatile platforms for virus detection, adaptable to various viral targets and detection principles.
- The review offers valuable insights for developing on-site aptasensors, particularly for emerging viral threats like SARS-CoV-2.
- Further research into aptasensor challenges and future directions is essential for advancing rapid diagnostics.
