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The Molecular Effects of BDNF Synthesis on Skeletal Muscle: A Mini-Review
I Rentería1, P C García-Suárez1,2, A C Fry2
1Facultad de Deportes, Universidad Autónoma de Baja California, Ensenada, Mexico.
Frontiers in Physiology
|July 25, 2022
Summary
Brain-derived neurotrophic factor (BDNF) is crucial for skeletal muscle function, aiding in neuromuscular junction strength and regeneration. This review explores BDNF production in muscle and its biological impacts.
Area of Science:
- Neuroscience
- Muscle Physiology
Background:
- Brain-derived neurotrophic factor (BDNF) is a key neurotrophin primarily produced in the brain.
- BDNF plays vital roles in synaptic modulation, neurogenesis, neuron survival, and angiogenesis.
- Skeletal muscle also synthesizes BDNF, contributing to muscle function and plasticity.
Purpose of the Study:
- To review current knowledge on BDNF production in skeletal muscle.
- To discuss the impact of BDNF on skeletal muscle biology.
Main Methods:
- Literature review of recent scientific works on BDNF in skeletal muscle.
Main Results:
- BDNF is synthesized in skeletal muscle and influences cellular mechanisms.
- Exercise stimuli enhance BDNF's role in neuromuscular junctions, muscle regeneration, and glucose metabolism.
- BDNF is involved in insulin-regulated glucose uptake and beta-oxidation in muscle tissue.
Conclusions:
- BDNF is a significant factor in skeletal muscle physiology.
- Understanding BDNF's role in muscle is vital for comprehending its overall physiological relevance.
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