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Natural tannins as anti-SARS-CoV-2 compounds.

Shao-Chun Wang1,2,3,4, I-Wen Chou3, Mien-Chie Hung1,2,3,4

  • 1Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan, 40402.

International Journal of Biological Sciences
|July 25, 2022
PubMed
Summary

Tannins, natural polyphenols found in fruits, show potential anti-COVID-19 properties. This review clarifies tannin species and their activities against SARS-CoV-2 for developing natural antiviral agents.

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Area of Science:

  • Phytochemistry
  • Virology
  • Natural Products Chemistry

Background:

  • Tannins are diverse polyphenols found in various plant parts, including fruits.
  • There's growing interest in tannins for antioxidant, anticancer, and food additive applications.
  • The COVID-19 pandemic spurred research into natural compounds for antiviral therapies.

Purpose of the Study:

  • To review the tannin family in fruits.
  • To summarize current knowledge on tannin activities against SARS-CoV-2.
  • To clarify tannin species and their antiviral potential for future pandemic preparedness.

Main Methods:

  • Literature review of scientific articles on tannins and SARS-CoV-2.
  • Analysis of the structural diversity and nomenclature of tannin compounds.

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Last Updated: Sep 3, 2025

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  • Evaluation of reported biological activities of fruit-derived tannins.

    • Main Results:

    • Tannins exhibit potential antiviral properties against SARS-CoV-2.
    • Structural diversity and misnomers complicate the identification of specific anti-COVID-19 tannins.
    • Fruit-derived tannins are a promising area for natural antiviral drug discovery.

    Conclusions:

    • Clarifying tannin nomenclature and structure is crucial for identifying effective antiviral agents.
    • Fruit tannins represent a valuable resource for developing natural compounds against SARS-CoV-2.
    • This review aids researchers in harnessing tannins for future pandemic interventions.