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Galectin-3 Involvement in Cognitive Processes for New Therapeutic Considerations.
Nataša R Mijailović1, Katarina Vesic2, Dragana Arsenijevic3
1Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Frontiers in Cellular Neuroscience
|July 25, 2022
Summary
Galectin-3 (Gal-3) impacts cognitive function and neuroinflammation. This review explores Gal-3
Area of Science:
- Neuroscience
- Immunology
- Biochemistry
Background:
- Cognitive impairment is linked to aging and neurodegenerative diseases.
- Early identification of cognitive decline risk is crucial for maintaining cognitive reserve.
- Galectin-3 (Gal-3) is implicated in neuroinflammation and neurodegeneration.
Purpose of the Study:
- To review recent findings on the relationship between Gal-3 and cognitive function.
- To elucidate the mechanisms by which Gal-3 influences cognitive impairment.
- To assess Gal-3's potential as a biomarker and therapeutic target.
Main Methods:
- Review of recent literature on Gal-3 in animal and human models.
- Focus on Gal-3's role in modulating neuroinflammation and microglial phenotype.
- Analysis of Gal-3's utility as a biomarker and therapeutic strategy.
Main Results:
- Gal-3 plays a role in modulating inflammatory responses.
- Gal-3 influences microglia morphology and phenotype.
- Evidence suggests Gal-3's involvement in cognitive impairment.
Conclusions:
- Gal-3 is a key player in neuroinflammation and neurodegeneration.
- Gal-3 holds potential as a biomarker for cognitive decline.
- Targeting Gal-3 may offer therapeutic strategies for neuropsychiatric diseases.
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