Enhancing Drug Utilization Efficiency via Dish-Structured Triboelectric Nanogenerator
Qu Chen1,2, Wenjing Deng3, Jingjin He2
1Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Frontiers in Bioengineering and Biotechnology
|July 25, 2022
Summary
This study introduces a self-powered drug delivery system using a disk triboelectric nanogenerator (D-TENG) to enhance chemotherapy. The system significantly increased cancer cell uptake of doxorubicin (DOX), offering a promising new treatment approach.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Cancer chemotherapy faces challenges with severe side effects and limited efficacy.
- There is a need for innovative drug delivery systems to improve therapeutic outcomes.
Purpose of the Study:
- To design and evaluate a self-powered drug delivery system using a disk triboelectric nanogenerator (D-TENG).
- To investigate the effect of electrical stimulation from the D-TENG on cancer cell drug uptake.
Main Methods:
- A self-powered drug delivery system was constructed using a D-TENG and gold electrodes.
- Cancer cells were cultured within the electrode gap and stimulated by the D-TENG's output current.
- The uptake of doxorubicin (DOX) by cancer cells under electrical stimulation was quantified.
Main Results:
- The D-TENG demonstrated stable current output (average 2.8 μA) with peak voltage of 135 V at 7.4 Hz.
- Electrical stimulation significantly enhanced the uptake of doxorubicin (DOX) by cancer cells.
- The D-TENG system showed good long-term stability for continuous current output.
Conclusions:
- The developed self-powered D-TENG system offers a novel approach for chemotherapy drug delivery.
- This technology has the potential to improve the efficacy of cancer treatment by enhancing drug uptake.
- Triboelectric nanogenerators represent a promising platform for future advancements in disease therapy.
