Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

192
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
192
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

198
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
198
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

297
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
297
Antimicrobial Proteins01:23

Antimicrobial Proteins

4.2K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
4.2K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

150
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
150
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

87
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
87

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolation and genomic analysis of otomycosis pathogens, and genomics-informed antimicrobial peptide design with potential therapeutic applications.

BMC microbiology·2026
Same author

Automated vision-language framework for kinematic profiling and performance diagnostics in competitive swimming.

BMC sports science, medicine & rehabilitation·2026
Same author

Physical activity interventions for executive function in adolescents: a systematic review and meta-analysis.

Psychology, health & medicine·2026
Same author

Self-distillation double student network for semi-supervised medical image segmentation.

Frontiers in physiology·2026
Same author

Blocking interaction of sclerostin loop3 with osteoblastic LRP4 counteracts bone loss without increasing arterial stiffness during mechanical unloading.

Journal of orthopaedic translation·2026
Same author

Mechanistic elucidation of strictosidine synthase-catalyzed Pictet-Spengler reaction for rare piperazine-indole scaffold formation.

Journal of molecular graphics & modelling·2026

Related Experiment Video

Updated: Sep 3, 2025

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
08:33

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

13.2K

Targeted Antimicrobial Agents as Potential Tools for Modulating the Gut Microbiome.

Shuli Chou1, Shiqing Zhang1, Huating Guo1

  • 1Center for Infection and Immunity Studies, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.

Frontiers in Microbiology
|July 25, 2022
PubMed
Summary

Targeted antimicrobial agents offer precise gut microbiome modulation to combat diseases caused by pathobionts. This review explores natural and synthetic options for developing next-generation microbiome-therapeutics.

Keywords:
antimicrobial peptidesbacteriocinsberberinemicrobiome editingpathobiontsphage therapypolyphenolstargeted drug delivery system

More Related Videos

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.7K
A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.4K

Related Experiment Videos

Last Updated: Sep 3, 2025

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
08:33

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

13.2K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.7K
A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.4K

Area of Science:

  • Microbiology
  • Pharmacology
  • Gastroenterology

Background:

  • The gut microbiome is crucial for host health, but pathobionts can drive disease progression.
  • Broad-spectrum antibiotics disrupt the microbiome and have side effects, necessitating targeted approaches.
  • Developing precise tools to modulate the gut microbiome is essential for therapeutic interventions.

Purpose of the Study:

  • To review narrow-spectrum and targeted antimicrobial agents for gut microbiome modulation.
  • To explore the potential of natural and synthetic agents in treating microbiome-involved diseases.
  • To highlight the role of pathobionts and emerging antimicrobial strategies.

Main Methods:

  • Literature review of natural antibiotics from plants and microorganisms.
  • Review of targeted synthetic agents, including peptides, phages, and drug delivery systems.
  • Analysis of antimicrobial strategies from the perspective of host health and microbiome modulation.

Main Results:

  • Natural and synthetic agents offer precise antimicrobial activity.
  • Phage therapy, synthetic peptides, and targeted drug delivery systems show promise.
  • These agents can selectively target pathobionts while preserving beneficial microbes.

Conclusions:

  • Targeted antimicrobial agents represent a new generation of therapeutics for microbiome-related diseases.
  • Precise modulation of the gut microbiome holds significant potential for improving host health.
  • Further research into these agents could lead to novel treatments for various conditions.