Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CT in ceroid lipofuscinosis.

D W Dunn

    Neurology
    |June 1, 1987
    PubMed
    Summary

    Neuronal ceroid lipofuscinosis (NCL) diagnosis in children can be challenging. Early cerebellar atrophy on CT scans may indicate NCL before cognitive decline or vision loss.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Behavior problems in children at time of first recognized seizure and changes over the following 3 years.

    Epilepsy & behavior : E&B·2011
    Same author

    Sympatric shift in a male sexual ornament in the damselfly Calopteryx splendens.

    Journal of evolutionary biology·2010
    Same author

    Neuropsychological status at seizure onset in children: risk factors for early cognitive deficits.

    Neurology·2009
    Same author

    Atomoxetine treatment in children and adolescents with ADHD and comorbid tic disorders.

    Neurology·2005
    Same author

    Male mating preference for female survivorship in the seaweed fly Gluma musgravei (Diptera: Coelopidae).

    Proceedings. Biological sciences·2001
    Same author

    Behavior problems in children before first recognized seizures.

    Pediatrics·2001

    Area of Science:

    • Neurology
    • Pediatrics
    • Medical Imaging

    Background:

    • Neuronal ceroid lipofuscinosis (NCL) comprises a group of inherited neurodegenerative disorders.
    • Diagnosis typically relies on clinical signs like seizures, dementia, and retinal changes, confirmed by biopsy.
    • Identifying NCL early is crucial for potential interventions.

    Observation:

    • Two pediatric patients presented with new-onset seizures.
    • Computed tomography (CT) scans were performed before significant intellectual deterioration or retinal changes were evident.
    • CT imaging revealed distinct cerebellar atrophy and enlarged fourth ventricle, without widespread cerebral atrophy.

    Findings:

    • The observed cerebellar atrophy and ventricular enlargement represent potential early radiological markers for NCL.
    • These specific CT findings appeared prior to the classic diagnostic indicators of dementia and retinal pathology.
    • This suggests a distinct pattern of neurodegeneration in the early stages of childhood NCL.

    Implications:

    • CT findings of cerebellar atrophy may aid in the earlier diagnosis of NCL in children presenting with seizures.
    • Integrating neuroimaging into the diagnostic pathway could improve detection rates.
    • Further research is warranted to validate these imaging findings as reliable early biomarkers for NCL.

    Related Experiment Videos