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Updated: Sep 3, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
Role of glycolysis in the development of atherosclerosis
Lanfang Li1, Min Wang1, Qiuxiao Ma2
1Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Abstract:
Atherosclerosis is a chronic inflammatory vascular disease associated with endothelial dysfunction, inflammation, and atherosclerotic plaque formation. Glycolysis is a conservative and rigorous biological process that decomposes glucose into pyruvate. Its function is to provide the body with energy and intermediate products required for life activities. However, abnormalities in glycolysis flux during the progression of atherosclerosis accelerate the disease progression. Herein, we review the role of glycolysis in the development of atherosclerosis to provide new ideas for devising novel antiatherosclerosis strategies.
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