Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mechanisms of Retrovirus-induced Cancers

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

ACUTE MYOCARDIAL DEGENERATION AND DEATH IN AYE-AYES (<i>DAUBENTONIA MADAGASCARIENSIS)</i> FOLLOWING INGESTION OF AVOCADO <i>(PERSEA AMERICANA)</i>.

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians·2026

Same author

PICALM::MLLT10 translocated leukemia.

FEBS letters·2026

Same author

Concurrent Congenital Umbilicobiliary Fistula and Vesicourachal Diverticula in a Dog.

Animals : an open access journal from MDPI·2025

Same author

Evaluation of chronic toxicity and carcinogenicity of HFPO-DA in mice.

Regulatory toxicology and pharmacology : RTP·2025

Same author

Detection of <i>Dirofilaria repens</i> and <i>Mansonella llewellyni</i> in the United States by <i>Wolbachia</i> Surveillance.

Transboundary and emerging diseases·2025

Same author

Recurrent integration of domestic cat hepatitis B virus DNA near feline CCNE1 supports an oncogenic role in hepatocellular carcinoma in cats.

Tumour virus research·2025

Same journal

An outbreak of H5N1 clade 2.3.4.4b highly pathogenic avian influenza in California condors (<i>Gymnogyps californianus)</i>.

Veterinary pathology·2026

Same journal

Histomorphologic evidence supports a hyperplastic pathogenesis of fibromatous epulis of periodontal ligament origin/peripheral odontogenic fibroma and proposal of fibromatous hyperplasia of the gingival ligament as unifying nomenclature.

Veterinary pathology·2026

Same journal

Image challenge in <i>veterinary pathology</i>.

Veterinary pathology·2026

Same journal

Image challenge in veterinary pathology, answers: Bovine diseases.

Veterinary pathology·2026

Same journal

Immunohistochemical detection of the transcription factor osterix in canine and feline osteosarcoma.

Veterinary pathology·2026

Same journal

Spontaneous rhabdomyosarcomas in <i>Dmd</i><sup><i>mdx</i></sup> rats.

Veterinary pathology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 3, 2025

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Hepatocellular carcinomas in captive prosimians.

Cynthia Robveille¹, John M Cullen²

¹Oniris, Nantes, France.

Veterinary Pathology

|July 25, 2022

Summary

This summary is machine-generated.

This study characterized hepatocellular carcinomas (HCCs) in prosimians, finding higher mitotic counts in metastatic tumors. Keratin 7 (K7) expression may indicate a poorer prognosis in these endangered primates.

Keywords:

cytokeratin 19 cytokeratin 7 hepatocellular carcinoma lemur metastasis neoplasm prosimians

More Related Videos

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

Related Experiment Videos

Last Updated: Sep 3, 2025

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

Area of Science:

Veterinary Pathology
Primate Oncology
Comparative Pathology

Background:

Hepatocellular carcinoma (HCC) is a significant neoplasm in captive prosimians.
Understanding fatal neoplasms in these endangered primates is crucial for conservation and welfare.
Previous characterization of HCCs in prosimians is limited.

Purpose of the Study:

To characterize spontaneous hepatocellular carcinomas (HCCs) in captive prosimians.
To identify potential histopathological and immunohistochemical markers associated with metastatic behavior.
To investigate the prognostic relevance of specific markers in prosimian HCCs.

Main Methods:

Retrospective examination of 14 spontaneous HCCs from captive prosimians (2003-2014).
Histopathological evaluation including pattern analysis and mitotic count.
Immunohistochemical analysis using hepatocyte paraffin 1 (HepPar-1), keratin 7 (K7), and keratin 19 (K19).

Main Results:

Trabecular pattern, multinucleated cells, and extramedullary hematopoiesis were common findings.
Metastatic HCCs exhibited significantly higher mitotic counts.
HepPar-1 was universally positive; K7 was frequently positive, especially in metastatic cases.
Higher K7 expression (>15% of cells) was significantly associated with metastatic HCCs.

Conclusions:

Keratin 7 (K7) expression in neoplastic hepatocytes is significantly higher in metastatic HCCs of prosimians.
K7 may serve as a prognostically relevant marker for HCC aggressiveness in captive prosimians.
Further research into prosimian HCC markers can aid in understanding and managing these neoplasms.