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Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
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Consensus Recommendations to Optimize Testing for New Targetable Alterations in Non-Small Cell Lung Cancer
Diana N Ionescu1, Tracy L Stockley2,3, Shantanu Banerji4,5
1BC Cancer, Department of Pathology, Vancouver, BC V5Z 4E6, Canada.
Current Oncology (Toronto, Ont.)
|July 25, 2022
Summary
Comprehensive molecular testing for non-small cell lung cancer (NSCLC) is crucial. Experts recommend reflexive panel testing at diagnosis and upon resistance to targeted therapy for optimal treatment decisions.
Area of Science:
- Oncology
- Molecular Diagnostics
- Genetics
Background:
- Non-small cell lung cancer (NSCLC) historically had poor outcomes.
- Targeted therapies have significantly improved NSCLC patient survival over the last decade.
- Increasing complexity of biomarker testing necessitates updated guidance.
Purpose of the Study:
- To provide consensus recommendations for molecular testing of targetable alterations in NSCLC.
- To guide management of the evolving standard-of-care in NSCLC.
- To optimize biomarker testing requirements and result reporting.
Main Methods:
- A multidisciplinary expert working group (medical oncology, pathology, clinical genetics) convened virtually.
- Consensus recommendations were developed based on expert discussion and current evidence.
- Focus on testing for new targetable alterations in NSCLC.
Main Results:
- Accurate and timely testing of all targetable alterations is vital for optimizing NSCLC management.
- Experts recommend reflexive comprehensive panel testing at NSCLC diagnosis.
- Biomarker testing is also recommended upon development of resistance to targeted therapy.
Conclusions:
- Molecular testing is key for treatment decisions and access to novel NSCLC therapies.
- Recommendations aim to optimize molecular testing strategies for targetable alterations.
- Standardized reporting is advised to enhance clarity and interpretation for clinicians.
