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Updated: Sep 3, 2025

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition
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Catalysts for Change: The Role of Nonprofits in Solving Single Ventricle Heart Disease

Kaitlin A Davis1, Diane M Pickles1, Kirstie E Keller1

  • 1Additional Ventures, Palo Alto, CA 94301, USA.

Journal of Cardiovascular Development and Disease
|July 25, 2022
PubMed

Insights

Single ventricle (SV) heart disease, a group of complex congenital heart defects (CHDs), presents a significant challenge. Strategic investment and cross-disciplinary collaboration are crucial for developing functional cures for SV and hypoplastic left heart syndrome (HLHS).

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Disease Research
  • Medical Innovation

Background:

  • Single ventricle (SV) heart disease encompasses a range of complex congenital heart defects (CHDs).
  • Hypoplastic left heart syndrome (HLHS) is a leading cause of mortality in infants with CHD.
  • Current understanding of SV etiology is incomplete, and curative solutions are limited.

Keywords:
congenital heart diseasefunding strategiesnonprofitphilanthropysingle ventricle

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