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Related Concept Videos

Per-Unit Sequence Models01:26

Per-Unit Sequence Models

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An ideal Y-Y transformer, grounded through neutral impedances, displays per-unit sequence networks akin to those of a single-phase ideal transformer when subjected to balanced positive- or negative-sequence currents. These currents do not produce neutral currents, and their associated voltage drops.
Zero-sequence currents, which are identical in magnitude and phase, generate a neutral current, resulting in voltage drops across the neutral impedance and the low-voltage winding. If the...
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Maxam-Gilbert Sequencing01:05

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In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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Next-generation Sequencing03:00

Next-generation Sequencing

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Sequence Networks of Rotating Machines01:24

Sequence Networks of Rotating Machines

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A Y-connected synchronous generator, grounded through a neutral impedance, is designed to produce balanced internal phase voltages with only positive-sequence components. The generator's sequence networks include a source voltage that is exclusively in the positive-sequence network. The sequence components of line-to-ground voltages at the generator terminals illustrate this configuration.
Zero-sequence current induces a voltage drop across the generator's neutral impedance and other...
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Sanger Sequencing01:57

Sanger Sequencing

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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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Labeling DNA Probes03:31

Labeling DNA Probes

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
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Updated: Sep 3, 2025

2D-HELS MS Seq: A General LC-MS-Based Method for Direct and de novo Sequencing of RNA Mixtures with Different Nucleotide Modifications
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Partial Sequence Labeling With Structured Gaussian Processes.

Xiaolei Lu, Tommy W S Chow

    IEEE Transactions on Neural Networks and Learning Systems
    |July 25, 2022
    PubMed
    Summary
    This summary is machine-generated.

    Structured Gaussian processes for partial sequence labeling (SGPPSL) provide uncertainty estimation and improve parameter learning by incorporating confidence measures. This novel approach enhances sequence labeling performance on various tasks.

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    Area of Science:

    • Machine Learning
    • Artificial Intelligence
    • Probabilistic Modeling

    Background:

    • Current partial sequence labeling models often lack uncertainty estimation.
    • Existing methods may use flawed ground-truth disambiguation, impacting parameter learning.
    • Max-margin frameworks are common but do not inherently provide prediction uncertainty.

    Purpose of the Study:

    • To introduce Structured Gaussian Processes for Partial Sequence Labeling (SGPPSL).
    • To develop a model that encodes prediction uncertainty.
    • To improve parameter learning by utilizing confidence measures for ground-truth labels.

    Main Methods:

    • Employing factor-as-piece approximation to manage complex graph structures.
    • Introducing confidence measures to weigh candidate labels effectively.
    • Utilizing variational lower bound optimization for parameter and confidence estimation.
    • Developing a weighted Viterbi algorithm for sequence prediction.

    Main Results:

    • SGPPSL successfully encodes uncertainty in predictions.
    • The model effectively utilizes ground-truth label information for parameter learning.
    • Experimental evaluations on multiple sequence labeling tasks demonstrate significant effectiveness.
    • The weighted Viterbi algorithm improves performance by handling label ambiguity.

    Conclusions:

    • SGPPSL offers a robust framework for partial sequence labeling with inherent uncertainty quantification.
    • The proposed methods enhance model selection and hyperparameter learning efficiency.
    • The approach effectively addresses challenges posed by partially annotated data and label ambiguity.