Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pathology of green sea turtle (Chelonia mydas): Mortalities in Gladstone Harbour, Queensland, Australia, 2017-2020.

Journal of comparative pathology·2026
Same author

The oncogenome of the domestic cat.

Science (New York, N.Y.)·2026
Same author

Whole-Transcriptome Analysis of Gene Expression in Canine Splenic Lymphoid Hyperplasia, Complex Hyperplasia, Histiocytic Sarcoma, and Stromal Sarcoma.

Animals : an open access journal from MDPI·2026
Same author

Emergence of Ophidiomyces ophidiicola, Nannizziopsis barbatae and Paranannizziopsis in free-ranging Australian reptiles.

Australian veterinary journal·2026
Same author

SARS-COV-2 Vaccination Response in Non-Domestic Species Housed at the Toronto Zoo.

Vaccines·2025
Same author

Estimating Variance of Log Standardized Incidence Ratios Assessing Health Care Providers' Performance: Comparative Analysis Using Bayesian, Bootstrap, and Delta Method Approaches.

JMIRx med·2025

Related Experiment Video

Updated: Sep 3, 2025

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System
05:33

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

215

Evaluation of a Probability-Based Predictive Tool on Pathologist Agreement Using Urinary Bladder as a Pilot Tissue.

Emily Jones1, Solomon Woldeyohannes1, Fernanda Castillo-Alcala2

  • 1School of Veterinary Science, The University of Queensland, Gatton, QLD 4343, Australia.

Veterinary Sciences
|July 25, 2022
PubMed
Summary

Veterinary pathologists showed significant variation in diagnosing bladder conditions. A new predictive tool improved agreement, highlighting the need for standardized data and high-quality whole-slide imaging in pathology.

Keywords:
bladder diseasecanineconcurrencefelineglass slidesinter-pathologist agreementpredictive modelingveterinary pathologywhole-slide images

More Related Videos

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model
06:12

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Published on: May 29, 2015

7.3K
Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

4.8K

Related Experiment Videos

Last Updated: Sep 3, 2025

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System
05:33

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

215
Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model
06:12

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Published on: May 29, 2015

7.3K
Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

4.8K

Area of Science:

  • Veterinary Pathology
  • Digital Pathology
  • Computational Pathology

Background:

  • Inter-pathologist variation is a known issue in veterinary pathology, often worsened by incomplete case information.
  • Discrepancies in interpreting inflammatory cell thresholds contribute to reduced agreement among pathologists.

Purpose of the Study:

  • To evaluate the impact of a predictive modeling tool on inter-pathologist agreement for bladder histology assessments.
  • To compare agreement using digital whole-slide images (WSI) versus glass slides, with and without clinical information.

Main Methods:

  • Four pathologists assessed bladder histology slides under three conditions: no information, with signalment/history, and with a predictive tool.
  • Assessments were repeated using both digital WSI and traditional glass slides.
  • Kappa agreement statistics were calculated to quantify inter-pathologist variation.

Main Results:

  • Initial agreement without information was low (kappa 7-37%).
  • Agreement improved with signalment/history (kappa 23-37%) and further with the predictive tool (kappa 31-42%).
  • Overall concurrence with the reference diagnosis was 60%.

Conclusions:

  • Predictive modeling shows potential for standardizing pathologist agreement in veterinary pathology.
  • High-quality WSI is crucial to minimize digitization effects on diagnostic agreement.
  • Standardization of tissue assessment and data quality is essential for improving veterinary diagnostic accuracy.