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Related Experiment Video

Updated: Sep 3, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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Retinal arcades in posterior microphthalmos: biometric correlation.

Ramesh Venkatesh1, Pranjal Mishra1, Harshita Nahata1

  • 1Department of Retina and Vitreous, Narayana Nethralaya, Karnataka, India.

Clinical & Experimental Optometry
|July 25, 2022
PubMed
Summary

Posterior microphthalmos (PM) is a rare eye condition. This study found PM eyes have thickened choroids and narrowed retinal blood vessels, correlating with shorter axial lengths and specific corneal changes.

Keywords:
Angiographymulticolouroptical coherence tomographypathogenesisposterior microphthalmos

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Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Medical Imaging

Background:

  • Posterior microphthalmos (PM) is a rare developmental disorder characterized by high hyperopia and short axial length.
  • Key features include retinal papillomacular folds and a relatively normal anterior segment.
  • Understanding the structural and vascular changes in PM is crucial for diagnosis and management.

Purpose of the Study:

  • To compare retinal arcade distance from the fovea in posterior microphthalmos (PM) cases versus controls.
  • To correlate axial shortening in PM eyes with various imaging findings.

Main Methods:

  • A retrospective comparative case series involving 24 eyes of 12 PM patients and 12 age/sex-matched controls.
  • Utilized optical coherence tomography (OCT), OCT-angiography, and Multicolour® imaging.
  • Analyzed axial length and corneal biometry, comparing findings between groups.

Main Results:

  • All PM eyes exhibited retinal papillomacular folds and retinal arcade narrowing.
  • PM eyes showed thickened central retina and choroid, shorter axial length, higher keratometry, and smaller corneal diameters.
  • OCT-angiography revealed denser vessel density and a reduced foveal avascular zone area in PM.

Conclusions:

  • Posterior microphthalmos is associated with significant choroidal thickening and retinal vascular arcade narrowing.
  • Intercorrelation of axial length, OCT, OCT-angiography, and corneal biometry provides insights into the pathogenesis of PM.
  • These findings aid in understanding the structural and vascular alterations in PM eyes.