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Bilateral primary extramedullary orbital plasmacytomas.

R S Gonnering

    Ophthalmology
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    This case study details an 81-year-old man with orbital extramedullary plasmacytomas. Treatment with radiation and chemotherapy led to a good response, with no tumor recurrence after five years.

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    Area of Science:

    • Oncology
    • Hematology
    • Ophthalmology

    Background:

    • Extramedullary plasmacytomas (EMPs) are rare plasma cell tumors.
    • Orbital involvement is uncommon but can present as bilateral tumors.
    • Distinguishing EMPs from multiple myeloma is crucial for prognosis and treatment.

    Observation:

    • An 81-year-old male presented with bilateral orbital masses.
    • Histopathology revealed extramedullary plasmacytomas positive for IgG-kappa light chains.
    • Serum and urine analysis confirmed monoclonal IgG-kappa and Bence Jones protein (kappa chains).

    Findings:

    • Systemic evaluation excluded disseminated disease (multiple myeloma or solitary bone myeloma).
    • The patient received radiation therapy and low-dose melphalan/prednisone.

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  • A sustained remission with no clinical tumor evidence was observed five years post-treatment.

    • Implications:

    • This case highlights the distinct clinical course and favorable prognosis of orbital EMPs compared to systemic plasma cell dyscrasias.
    • It underscores the importance of thorough staging to differentiate orbital EMP from multiple myeloma.
    • Successful management with combined modality treatment offers a therapeutic option for localized orbital plasmacytomas.