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The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort
Gyurin Kim1, Soo Jung Rim1, Minkyung Jo1
1Department of Research Planning, Seoul, Korea.
Objective:
To investigate the cumulative effect of antipsychotics at different dosages on mortality in patients with schizophrenia.
Methods:
We analyzed data from the Korean National Health Insurance System-National Sample Cohort covering the 2002-2013 period. We used Cox regression analysis to calculate hazard ratios for mortality risks according to cumulative antipsychotic exposure levels (low, moderate, and high).
Results:
Our analyses revealed no significant association between antipsychotic exposure and mortality (either all-cause or cause-specific) in patients with schizophrenia.
Conclusion:
Our results imply that the excess mortality of patients with schizophrenia is attributable to factors other than antipsychotic usage.
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