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Endogenous Clostridium panophthalmitis.

M T Green, R L Font, J V Campbell

    Ophthalmology
    |April 1, 1987
    PubMed
    Summary
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    A rare Clostridium septicum infection caused a diabetic man to rapidly lose vision and die. This case highlights the severe ocular complications and rapid progression of this gas-forming organism.

    Area of Science:

    • Ophthalmology
    • Infectious Diseases
    • Gastroenterology

    Background:

    • Clostridium septicum is a rare but aggressive gas-forming bacterium.
    • Ocular involvement by C. septicum is exceptionally uncommon, with few documented cases.

    Observation:

    • A 61-year-old diabetic male presented with sudden, severe left eye pain, redness, and vision loss.
    • Ophthalmologic examination revealed a gas bubble in the anterior chamber and inability to perceive light.
    • Vitreous tap identified gram-positive rods, later cultured as Clostridium septicum.

    Findings:

    • The patient also had a ruptured sigmoid colon diverticulum with peritonitis, indicating a systemic source.
    • Histopathology of the eye showed extensive necrosis and C. septicum within intraocular structures.

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  • Despite treatment, the patient died within 24 hours of admission.

    • Implications:

    • This case represents the second reported instance of C. septicum panophthalmitis.
    • It underscores the potential for rapid, devastating ocular complications from C. septicum originating from gastrointestinal sources.
    • Highlights the importance of considering systemic infections in severe, unexplained ocular disease.