Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Somatosensation01:33

Somatosensation

38.3K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
38.3K
Anxiety: Overview01:18

Anxiety: Overview

339
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
339
Sensory Perception: Organization of the Somatosensory System01:11

Sensory Perception: Organization of the Somatosensory System

5.3K
The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the...
5.3K
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

1.2K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
1.2K
Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

5.3K
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
5.3K
Social Anxiety Disorder01:28

Social Anxiety Disorder

77
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
77

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human hippocampal ripples tune cortical responses based on predicted uncertainty.

Nature neuroscience·2026
Same author

Objective quality assessment for precision functional MRI data.

Neuron·2026
Same author

Unraveling the Complexity of Multilingual Comprehension: Neuroimaging and Linguistic Profiling in 700+ Adults.

Scientific data·2026
Same author

Testing and tracking in the UK: A dynamic causal modelling study.

Wellcome open research·2026
Same author

Targeting a genomic RNA G-quadruplex of dengue virus with small molecules as an alternative to protein-targeted therapeutics.

Journal of biomedical science·2026
Same author

The evolutionary and organizational bases of active affordance.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same journal

Fish oil-derived fatty acids during pregnancy and risk of neurodevelopmental disorders in children at age 10 - A randomized controlled trial.

Translational psychiatry·2026
Same journal

Cerebellar hypermetabolism disrupts fronto-cerebellar resting-state functional connectivity and associated executive compensation.

Translational psychiatry·2026
Same journal

Medium-intensity aerobic exercise can relieve mice anxiety by activating cannabinoid type 1 receptors on medial prefrontal cortex GABAergic neurons.

Translational psychiatry·2026
Same journal

Aberrant multivariate mapping between behavioral profiles and cortical morphological brain networks in children with autism spectrum disorder.

Translational psychiatry·2026
Same journal

In the Search for Suicide Signatures, Phenotype Matters.

Translational psychiatry·2026
Same journal

Early life social defeat in mice reduces prefrontal innervation of downstream structures in a regionally specific manner.

Translational psychiatry·2026
See all related articles

Related Experiment Video

Updated: Sep 3, 2025

Reducing State Anxiety Using Working Memory Maintenance
08:17

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

7.6K

Enhanced top-down sensorimotor processing in somatic anxiety.

Ismail Bouziane1,2, Moumita Das3, Karl J Friston4,5,6

  • 1Basque Center on Cognition, Brain and Language, San Sebastian, Spain.

Translational Psychiatry
|July 25, 2022
PubMed
Summary
This summary is machine-generated.

This study reveals that heightened top-down brain connectivity in sensorimotor areas is linked to somatic anxiety symptoms. This finding offers a potential biomarker for assessing anxiety

More Related Videos

Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment
07:20

Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment

Published on: March 8, 2019

13.7K
Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
10:51

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Published on: January 20, 2012

21.4K

Related Experiment Videos

Last Updated: Sep 3, 2025

Reducing State Anxiety Using Working Memory Maintenance
08:17

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

7.6K
Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment
07:20

Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment

Published on: March 8, 2019

13.7K
Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
10:51

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Published on: January 20, 2012

21.4K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Anxiety research often focuses on psychological, not somatic, symptoms.
  • Top-down cortical processing is vital for perception and action.
  • Understanding somatic anxiety mechanisms is crucial for effective treatment.

Purpose of the Study:

  • To investigate effective connectivity in sensorimotor networks related to somatic anxiety.
  • To identify potential neuroimaging biomarkers for somatic anxiety.
  • To explore the dissociation between somatic and cognitive anxiety dimensions.

Main Methods:

  • Utilized resting-state functional MRI data from the Human Connectome Project.
  • Employed Dynamic Causal Modeling (DCM) to analyze effective connectivity.
  • Focused on hierarchically organized regions in exteroceptive, interoceptive, and motor cortices.

Main Results:

  • Enhanced top-down effective connectivity was observed in sensorimotor networks in individuals with high somatic arousal.
  • Connectivity changes reliably predicted mild versus severe somatic anxiety.
  • Increased top-down connections to sensorimotor cortex were independent of fear affect scores.

Conclusions:

  • Enhanced top-down effective connectivity in sensorimotor cortices is a potential quantifiable marker for trait somatic anxiety.
  • This finding highlights the role of sensorimotor circuits in the somatic experience of anxiety.
  • The study supports a relative dissociation between somatic and cognitive aspects of anxiety.