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Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
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Beyond controlling cell size: functional analyses of S6K in tumorigenesis

Xueji Wu1,2, Wei Xie2, Wenxuan Xie1

  • 1Department of Liver Surgery, Hepatobiliary Pancreatic Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 5100080, China.

Cell Death & Disease
|July 25, 2022
PubMed

Insights

Ribosomal protein S6 kinase (S6K) controls cell size and protein synthesis. Emerging research reveals S6K

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Ribosomal protein S6 kinase (S6K) is a key effector of mTORC1, traditionally linked to cell size control.
  • Canonical functions involve regulating mRNA transcription, splicing, and protein synthesis.
  • Recent findings indicate diverse roles beyond cell size, influenced by various stimuli and regulators.

Purpose of the Study:

  • To comprehensively review the multifaceted roles of S6K.
  • To explore its upstream regulators and downstream substrates.
  • To highlight S6K as a potential therapeutic target in cancer.

Main Methods:

  • Literature review of existing research on S6K.
  • Analysis of studies on upstream regulators and downstream effectors.
  • Examination of mouse models and clinical relevance.

Main Results:

  • S6K activity is modulated by diverse stimuli, impacting numerous downstream substrates.
  • Beyond cell size, S6K influences apoptosis, metabolism, and feedback regulation.
  • Identified emerging upstream regulators and downstream targets of S6K.

Conclusions:

  • S6K possesses diverse pathobiological functions beyond its canonical role in cell size.
  • Understanding S6K's complex signaling network is crucial.
  • S6K represents a promising therapeutic target for various cancers.

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