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Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study

Frederik Faergemann Lau1, Signe Bollerup1, Frederik Engsig1

  • 1Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark.

Clinical Epidemiology
|July 26, 2022
PubMed

Insights

This study found no increased risk of ischemic heart disease (IHD) in individuals with chronic hepatitis B virus (CHB) infection compared to the general population. The findings suggest CHB does not significantly impact IHD rates.

Area of Science:

  • Cardiology
  • Hepatology
  • Epidemiology

Background:

  • Conflicting data exists regarding the association between chronic hepatitis B virus (CHB) infection and the risk of ischemic heart disease (IHD).
  • Understanding this relationship is crucial for comprehensive patient management and risk stratification.

Purpose of the Study:

  • To investigate the rate of IHD in patients diagnosed with CHB.
  • To compare the incidence of IHD in CHB patients against a matched cohort from the general population.

Main Methods:

  • A nationwide cohort study utilizing prospectively collected data from Danish registries.
  • Inclusion of 6472 individuals with CHB and 62,251 matched controls.
  • Analysis involved cumulative incidence curves, incidence rate ratios (IRR), and cause-specific Cox regression.

Main Results:

  • The crude IRR for IHD in CHB patients versus controls was 1.13 (95% CI: 0.91-1.39).
  • After adjusting for confounding factors, the hazard ratio for IHD in CHB patients was 0.96 (95% CI: 0.76-1.21).
  • No statistically significant difference in IHD rates was observed between the CHB cohort and the general population.

Conclusions:

  • This large-scale cohort study indicates that CHB infection is not associated with an increased risk of developing IHD.
  • The findings suggest that current management strategies for CHB do not need to be altered based on IHD risk.
Abstract

Keywords:
atherosclerosiscardiovascular diseasecoronary heart diseasegeneral populationhepatitis B virusischemic heart diseaseviral infection

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