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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: Sep 3, 2025

Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples
07:32

Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples

Published on: June 15, 2012

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Isolation of circulating tumor cells.

Jon F Edd1,2, Avanish Mishra1,2,3, Kyle C Smith4

  • 1BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Iscience
|July 26, 2022
PubMed
Summary
This summary is machine-generated.

Isolating rare circulating tumor cells (CTCs) from blood is crucial for personalized cancer treatment. Advanced microfluidic technologies offer high-throughput methods for pure CTC isolation, overcoming challenges like EpCAM absence.

Keywords:
BiotechnologyCell biologyTechnical aspects of cell biology

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Last Updated: Sep 3, 2025

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Area of Science:

  • Oncology
  • Biotechnology
  • Cellular Biology

Background:

  • Circulating tumor cells (CTCs) are vital for cancer metastasis.
  • CTCs offer molecular insights for personalized cancer therapy.
  • CTC isolation is challenging due to their rarity and similarity to leukocytes.

Purpose of the Study:

  • To provide a comprehensive overview of CTC isolation technologies.
  • To analyze key separation modes and integrated strategies for CTCs.
  • To highlight recent advancements in microfluidic-based CTC sorting.

Main Methods:

  • Analysis of various CTC isolation techniques.
  • Focus on microfluidic devices for cell separation.
  • Discussion of multi-dimensional cell sorting.

Main Results:

  • Microfluidics enables high-throughput isolation of CTCs.
  • Advanced methods address challenges like EpCAM-negative CTCs.
  • Progress in purity and yield of isolated CTCs.

Conclusions:

  • CTC isolation technologies are rapidly evolving, particularly in microfluidics.
  • Improved CTC isolation is key to advancing personalized oncology.
  • Microfluidics shows great promise for multi-parameter CTC sorting.