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Updated: Sep 3, 2025

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Simultaneous presentation of idiopathic uveitis in monozygotic 4-year-old twin boys
Sarah Baxter1, Russell N Van Gelder2,3, Jason C Cheung4
1Division of Rheumatology, Department of Pediatrics, University of Washington School of Medicine/Seattle Children's Hospital, Seattle, WA, USA.
Purpose:
To report monozygotic twin 4-year-old boys with chronic bilateral anterior uveitis with simultaneous onset.
Observations:
Here we report monozygotic twin 4-year-old boys with chronic bilateral anterior uveitis. The boys had simultaneous onset of uveitis and identical features. Evaluation, including whole exome sequencing (WES), failed to reveal a specific causative etiology. Each patient responded well to immune modulation and achieved uveitis remission on methotrexate monotherapy off topical glucocorticoids.
Conclusions And Importance:
From this case of monozygotic twin boys presenting with chronic uveitis, we conclude that monozygotic twins may warrant evaluation in the setting of idiopathic uveitis, especially in young patients unable to express an adequate history.
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