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Updated: Sep 3, 2025
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Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta
Published on: February 7, 2018
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Risk Factors for Incomplete Aortic Remodeling With Stent-Assisted Balloon-Induced Intimal Disruption and Relamination
Fabien Vecchini1,2, Gautier Haupert3, Anna Baudry4
1Department of Vascular Surgery, APHM, Timone Hospital, Marseille, France.
Summary
The STABILISE technique effectively treats aortic dissection, achieving complete aortic remodeling in most patients. However, severe angulation and chronic dissection increase risks, necessitating careful patient selection and follow-up.
Area of Science:
- Vascular Surgery
- Cardiovascular Research
- Medical Device Technology
Background:
- Aortic dissection poses significant risks, often requiring advanced treatment strategies.
- The STABILISE technique offers a method to extend treatment to the thoracoabdominal aorta.
- Complete aortic remodeling is a key goal in managing aortic dissection.
Purpose of the Study:
- To evaluate the short- and midterm anatomical outcomes of the STABILISE technique.
- To assess the efficacy of STABILISE in achieving complete aortic remodeling.
- To identify risk factors for incomplete remodeling after STABILISE treatment.
Main Methods:
- Retrospective analysis of patients treated with STABILISE for complicated aortic dissection.
- Multicenter study across 3 French academic centers.
- Measurement of aortic diameters preoperatively, postoperatively, and at 1-year follow-up using CT scans.
Main Results:
- Complete aortic remodeling achieved in 81.8% of patients; false lumen thrombosis in 94.5%.
- Significant decrease in maximal thoracic aortic diameter observed at 1 year.
- Severe aortic angulation and chronic aortic dissection were risk factors for incomplete remodeling.
Conclusions:
- The STABILISE technique is effective for aortic dissection, promoting thrombosis and remodeling.
- Incomplete intimal flap reapposition, linked to angulation and chronic dissection, increases aortic diameter.
- Close follow-up and careful patient selection are crucial for STABILISE application.
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