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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
Published on: October 22, 2014
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Association between platelet distribution width and peripheral arterial disease in elderly patients
Jiaxing Ke1, Nan Lu1, Yucheng Liu1
1Fujian Medical University, Fuzhou, Fujian, China.
VASA. Zeitschrift Fur Gefasskrankheiten
|July 26, 2022
Summary
Platelet distribution width (PDW) is significantly higher in elderly patients with peripheral arterial disease (PAD). This finding suggests PDW may serve as a valuable indicator for PAD in older populations.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Hematology
Background:
- Peripheral arterial disease (PAD) prevalence escalates with age.
- Platelet activation is implicated in PAD pathogenesis.
- Platelet distribution width (PDW) reflects platelet function.
Purpose of the Study:
- To investigate the association between PDW and PAD in an elderly cohort.
- To evaluate the diagnostic utility of PDW for PAD.
Main Methods:
- Retrospective study of 416 elderly patients.
- PAD diagnosis based on ankle-brachial index (ABI) < 0.9.
- Multivariate logistic regression and ROC curve analysis were employed.
Main Results:
- Higher PDW levels observed in patients with PAD (13.19±2.24%) compared to controls (11.52±1.39%).
- PDW showed a significant association with PAD (OR: 1.821, p<0.001) after adjustment.
- The association was more pronounced in females, with higher AUC values.
Conclusions:
- Elevated PDW is linked to PAD in the elderly.
- PDW demonstrates potential as a diagnostic marker for PAD, particularly in women.
- The association between PDW and PAD remains significant after accounting for confounders.
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