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Correction: Shyamsunder et al. THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors. <i>Int. J. Mol. Sci.</i> 2022, <i>23</i>, 1207.

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The evolution of immune dysfunction in multiple myeloma.

Cinnie Yentia Soekojo1,2,3, Wee Joo Chng1,2,3

  • 1Department of Hematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore.

European Journal of Haematology
|July 26, 2022
PubMed
Summary

Immune dysfunction significantly impacts multiple myeloma (MM) progression and treatment resistance. Understanding these immune changes is key to developing new immunotherapies for MM.

Keywords:
immunitymonoclonal gammopathy of undetermined significancemultiple myelomasmoldering multiple myeloma

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Area of Science:

  • Immunology
  • Oncology
  • Hematology

Background:

  • Multiple myeloma (MM) is a hematologic malignancy characterized by immune dysregulation.
  • Immune dysfunction is implicated in the pathogenesis and progression of MM.

Purpose of the Study:

  • To review the role of immune dysfunction across all stages of multiple myeloma.
  • To highlight the importance of immune system function in MM development and treatment.

Main Methods:

  • This study is a narrative review.
  • Literature search on immune dysfunction in multiple myeloma.

Main Results:

  • Immune dysfunction plays a critical role in multiple myeloma (MM) pathogenesis, disease progression, and resistance to therapies.
  • The progression from asymptomatic precursor states to active MM is associated with a worsening of immune system impairment.

Conclusions:

  • Understanding the immune system's role in MM progression is crucial for advancing immunotherapeutic strategies.
  • Targeting immune dysfunction may offer novel therapeutic avenues for multiple myeloma patients.