The evolution of immune dysfunction in multiple myeloma
Related Experiment Video
Updated: Sep 3, 2025

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
Cinnie Yentia Soekojo1,2,3, Wee Joo Chng1,2,3
1Department of Hematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore.
Objectives:
This review discusses the role of immune dysfunction at the different stages of multiple myeloma (MM).
Methods:
Narrative review.
Results:
MM is a complex disease and immune dysfunction has been known to play an important role in disease pathogenesis, progression, and drug resistance. MM is known to be preceded by asymptomatic precursor states and progression from the precursor states to MM is likely related to a progressive impairment of the immune system.
Conclusions:
An understanding of the role of the immune system in the progression of MM is important to guide the development of immunotherapeutic strategies for this disease.
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