Treatment horizon in multiple myeloma
Cinnie Yentia Soekojo1,2,3, Wee Joo Chng1,2,3
1Department of Hematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore.
New therapies for multiple myeloma (MM) are expanding, offering hope. Emerging treatments targeting immune dysfunction show promise for improving patient survival in this complex blood cancer.
Area of Science:
- Hematology
- Oncology
- Immunotherapy
Background:
- Multiple myeloma (MM) is a complex and heterogeneous hematologic malignancy.
- Treatment landscape for MM has evolved significantly in recent years.
Purpose of the Study:
- To review current and emerging therapeutic strategies for multiple myeloma.
- To highlight advancements in MM treatment.
Main Methods:
- This study employed a narrative review methodology.
- Comprehensive literature search on MM therapies was conducted.
Main Results:
- Multiple myeloma is characterized by significant heterogeneity.
- Recent advancements include enhanced monoclonal antibodies, antibody-drug conjugates, bispecific T-cell engagers, and chimeric antigen-T-cell therapy.
- Several novel treatment modalities are currently under development.
Conclusions:
- Emerging therapies targeting MM-associated immune dysfunction are improving patient outcomes.
- These novel treatments have led to significant improvements in overall survival for multiple myeloma patients.
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