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Updated: Sep 3, 2025
08:35
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
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New and developing pharmacotherapies for hypertension
Christian Höcht1,2, Miguel A Allo1,2, Ariel Héctor Polizio1,2
1Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Farmacología, Buenos Aires, Argentinaa.
Expert Review of Cardiovascular Therapy
|July 26, 2022
Summary
New antihypertensive drugs and strategies are emerging to combat poor hypertension control globally. Innovations include novel drug mechanisms, optimized formulations, and targeting gut microbiota for better blood pressure management.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Microbiome Research
Background:
- Hypertension remains a major global health challenge with inadequate disease control.
- Novel pharmacological agents and therapeutic strategies are crucial for managing hypertension.
Purpose of the Study:
- To review recent advances in emerging pharmacological agents for hypertension management.
- To cover innovations in drug formulations and the role of gut microbiota in blood pressure control.
Main Methods:
- Review of current research on novel antihypertensive drug development.
- Analysis of technological innovations in drug formulation.
- Exploration of the impact of intestinal microbiota on hypertension.
Main Results:
- Emerging drugs like sacubitril/valsartan and SGLT2 inhibitors show promise for difficult-to-control hypertension.
- Firibastat and aprocitentan offer novel mechanisms for resistant hypertension.
- Prebiotics and probiotics may help prevent hypertension and aid blood pressure control by addressing gut dysbiosis.
Conclusions:
- Novel pharmacological agents and gut microbiota modulation represent promising strategies for improved hypertension management.
- Targeting specific mechanisms in resistant hypertension is advancing therapeutic options.
- Personalized approaches considering gut health may enhance blood pressure control.
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