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Published on: January 3, 2013
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[PD-L1 expression in EBV-associated gastric carcinomas].
N V Danilova1, T N Sotnikova2, D V Kalinin3
1Lomonosov Moscow State University - Medical Scientific and Educational Center, Moscow, Russia.
Arkhiv Patologii
|July 26, 2022
Summary
PD-L1 expression is frequent in Epstein-Barr virus-associated gastric cancer, often seen in younger males with specific tumor characteristics. However, PD-L1 status alone does not significantly impact prognosis in these patients.
Area of Science:
- Oncology
- Gastroenterology
- Immunology
Background:
- Epstein-Barr virus (EBV) is implicated in a subset of gastric adenocarcinomas.
- Programmed death-ligand 1 (PD-L1) is a key immune checkpoint target in cancer therapy.
- Understanding PD-L1 expression in EBV-associated gastric cancer is crucial for therapeutic strategies.
Purpose of the Study:
- To assess the incidence of PD-L1 expression in EBV-associated gastric adenocarcinomas.
- To characterize the clinical and morphological features of PD-L1-positive EBV-associated gastric cancer.
- To determine the median survival of patients with PD-L1-positive EBV-associated gastric cancer.
Main Methods:
- Studied 127 gastric cancer patient samples.
- Used in situ hybridization for EBV detection (EBER).
- Assessed PD-L1 expression via immunohistochemistry (SP263 and SP142 clones).
- Correlated PD-L1 status with clinical, morphological characteristics, and survival data.
Main Results:
- PD-L1 expression was detected in 100% (SP263) and 76.9% (SP142) of EBV-associated gastric adenocarcinomas.
- PD-L1-positive patients were younger, predominantly male, with proximal tumors, ulcerative growth, and tubular histology.
- Median survival for PD-L1 positive (SP263) was 35 months, and for PD-L1 positive (SP142) was 25 months.
- PD-L1 status was not found to be a significant prognostic factor independently.
Conclusions:
- PD-L1 expression is highly prevalent in EBV-associated gastric cancer.
- Clinical and morphological factors, especially tumor stage, are more critical for prognosis than PD-L1 status alone.
- PD-L1 assessment should be considered alongside traditional prognostic indicators.
