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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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A standardised nomenclature for long non-coding RNAs.

Ruth L Seal^1,2, Susan Tweedie¹, Elspeth A Bruford^1,2

¹HUGO Gene Nomenclature Committee, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.

|July 26, 2022

Summary

The HUGO Gene Nomenclature Committee (HGNC) standardizes human gene symbols, including long non-coding RNA (lncRNA) genes. This ensures clear communication and accurate data retrieval in research and databases.

Keywords:

gene names gene symbols human genes lncRNA standardisation

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Area of Science:

Genetics
Molecular Biology
Bioinformatics

Background:

Standardized gene nomenclature is crucial for clear scientific communication.
The HUGO Gene Nomenclature Committee (HGNC) is the authoritative body for human gene symbol approval.
Long non-coding RNA (lncRNA) genes require consistent naming conventions.

Purpose of the Study:

To describe the HGNC's process for naming lncRNA genes.
To review the nomenclature of frequently cited lncRNA genes.
To emphasize the importance of approved gene symbols for searchability and data integrity.

Main Methods:

Analysis of HGNC lncRNA gene naming guidelines.
Review of scientific literature to identify highly mentioned lncRNA genes.
Examination of the nomenclature applied to selected lncRNA genes.

Main Results:

The HGNC employs specific criteria for assigning symbols to lncRNA genes.
A review of seven prominent lncRNA genes highlights current naming practices.
Approved symbols prevent ambiguity and enhance database and publication searchability.

Conclusions:

Consistent lncRNA gene nomenclature, managed by the HGNC, is essential for the biomedical community.
Adherence to HGNC guidelines facilitates accurate data sharing and reduces research errors.
Standardized symbols improve the discoverability of lncRNA research.