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Neoantigen-Specific T Cells in Adoptive Cell Therapy

Eric Tran1

  • 1From the Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR.

Cancer Journal (Sudbury, Mass.)
|July 26, 2022
PubMed

Insights

Targeting cancer neoantigens with adoptive cell therapy offers a promising strategy for destroying tumor cells while sparing normal tissues. This approach leverages unique mutations for specific immune recognition in epithelial cancers.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Therapeutics

Background:

  • Cancer cells possess unique somatic mutations distinguishing them from normal tissues.
  • Nonsynonymous mutations can generate mutated peptide antigens, known as neoantigens.
  • Neoantigens are specifically recognized by T cells, forming the basis for targeted therapies.

Purpose of the Study:

  • To review the clinical application of adoptive cell therapy (ACT) targeting neoantigens.
  • To highlight the potential of neoantigen-based immunotherapy in treating epithelial cancers.

Main Methods:

  • Review of existing clinical studies and literature on neoantigen-targeted ACT.
  • Focus on strategies for identifying and targeting neoantigens in epithelial cancers.

Main Results:

  • Neoantigen-specific T cell recognition offers a potential pathway for selective cancer cell destruction.
  • Adoptive cell therapy targeting neoantigens shows promise as a safe and effective cancer treatment strategy.

Conclusions:

  • Immunological targeting of neoantigens is a safe and promising strategy for cancer treatment.
  • Clinical application of neoantigen-targeted adoptive cell therapy is being explored for epithelial cancers.

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