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Published on: July 29, 2019
Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain
Lucy Zhao1, Allen Tannenbaum2,3, Erik N T P Bakker4
1Department of Anesthesiology, Yale School of Medicine, New Haven, Connecticut.
Abstract:
This review focuses on the physiology of glymphatic solute transport and waste clearance, using evidence from experimental animal models as well as from human studies. Specific topics addressed include the biophysical characteristics of fluid and solute transport in the central nervous system, glymphatic-lymphatic coupling, as well as the role of cerebrospinal fluid movement for brain waste clearance. We also discuss the current understanding of mechanisms underlying increased waste clearance during sleep.
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