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Updated: Sep 3, 2025

Analyzing Long-Term Electrocardiography Recordings to Detect Arrhythmias in Mice
Published on: May 23, 2021
Visualization deep learning model for automatic arrhythmias classification
Mingfeng Jiang1, Yujie Qiu1, Wei Zhang1
1School of Information Science and Technology, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China.
Insights
A new hybrid deep learning model combining Resnet and GRU effectively classifies cardiac arrhythmias from ECGs. This explainable AI approach improves diagnostic accuracy for cardiovascular diseases.
Area of Science:
- Cardiology
- Artificial Intelligence
- Biomedical Engineering
Background:
- Heart disease is a leading global health threat.
- Electrocardiography (ECG) is crucial for diagnosing cardiovascular conditions.
- Automating arrhythmia classification is vital due to increasing ECG data and cardiologist shortages.
Purpose of the Study:
- To enhance the accuracy of detecting abnormal ECG patterns.
- To develop an automated system for classifying cardiac arrhythmias.
- To improve the interpretability of deep learning models in ECG analysis.
Main Methods:
- A hybrid 1D Resnet-GRU deep learning model was developed for 12-lead ECG analysis.
- The focal loss function was employed to address dataset imbalance.
- Grad-CAM++ was utilized for class-discriminative visualization to enhance model transparency.
Main Results:
- The 1D Resnet-GRU model achieved an F1-score of 0.821 in classifying 9 types of arrhythmias.
- Grad-CAM++ provided insights into the model's predictions, aligning with clinical arrhythmia diagnosis.
- The method demonstrated effective feature selection and integration for end-to-end classification.
Conclusions:
- The proposed hybrid deep learning model offers a promising approach for automated arrhythmia classification using 12-lead ECG.
- The integration of Grad-CAM++ provides an explainable AI framework for clinical decision support.
- This method facilitates accurate and transparent diagnosis of cardiovascular diseases.
Abstract:
Objective.With the improvement of living standards, heart disease has become one of the common diseases that threaten human health. Electrocardiography (ECG) is an effective way of diagnosing cardiovascular diseases. With the rapid growth of ECG examinations and the shortage of cardiologists, accurate and automatic arrhythmias classification has become a research hotspot. The main purpose of this paper is to improve accuracy in detecting abnormal ECG patterns.Approach.A hybrid 1D Resnet-GRU method, consisting of the Resnet and gated recurrent unit (GRU) modules, is proposed to implement classification of arrhythmias from 12-lead ECG recordings. In addition, the focal Loss function is used to solve the problem of unbalanced datasets. Based on the proposed 1D Resnet-GRU model, we use class-discriminative visualization to improve interpretability and transparency as an additional step. In this paper, the Grad-CAM++ mechanism has been employed to the trained network model and generate thermal images superimposed on raw signals to explore underlying explanations of various ECG segments.Main results.The experimental results show that the proposed method can achieve a high score of 0.821 (F1-score) in classifying 9 kinds of arrythmias, and Grad-CAM++ not only provides insight into the predictive power of the model, but is also consistent with the diagnostic approach of the arrhythmia classification.Significance.The proposed method can effectively select and integrate ECG features to achieve the goal of end-to-end arrhythmia classification by using 12-lead ECG signals, which can serve a promising and useful way for automatic arrhythmia classification, and can provide an explainable deep leaning model for clinical diagnosis.
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