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Related Experiment Video

Updated: Sep 3, 2025

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

Microbiota and lung cancer.

Taichiro Goto¹

¹Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, Kofu, Yamanashi 4008506, Japan.

Seminars in Cancer Biology

|July 26, 2022

Summary

The airway microbiome, or bacterial flora in the lungs, plays a role in lung cancer development and progression. Understanding these microbial communities may lead to new cancer prevention and treatment strategies.

Area of Science:

Microbiology
Oncology
Genomics

Background:

Traditional bacterial studies relied on culture methods, limiting research to culturable species.
Next-generation sequencing (NGS) revolutionized microbial research, revealing diverse bacterial communities in previously sterile environments like the lower respiratory tract.
Dysbiosis, an imbalance in the microbiome, is increasingly linked to various diseases, including cancer.

Purpose of the Study:

To review the basic mechanisms and molecular functions of the airway microbiome in oncogenesis.
To explore strategies for cancer prevention utilizing airway microbiota.
To summarize the role of the microbiome in modulating immunotherapies for lung cancer.

Main Methods:

Genomic analysis using next-generation sequencing (NGS).

Keywords:

Immunotherapy Inflammation Lung cancer Microbiome Oncogenesis

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Last Updated: Sep 3, 2025

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Published on: October 26, 2017

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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Published on: October 15, 2019

Review of recent research on cancer-associated microbial communities.

Analysis of interactions among bacteria, tumors, and immune cells.

Main Results:

The lower respiratory tract harbors a diverse bacterial microbiome.
Microbial dysbiosis is associated with lung oncogenesis.
Bacteria may trigger tumor initiation and progression via toxins and inflammatory factors.

Conclusions:

The airway microbiome significantly influences lung cancer development.
Targeting the airway microbiota offers potential for cancer prevention.
The microbiome modulates immunotherapy efficacy in lung cancer.