Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemagglutination tests for syphilis antibody.

H W Jaffe, S A Larsen, O G Jones

    American Journal of Clinical Pathology
    |August 1, 1978
    PubMed
    Summary

    The MHA-TP test shows high sensitivity and specificity for syphilis serodiagnosis, comparable to FTA-ABS. The TPHA test requires further study due to potential undersensitivity in syphilis diagnosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Time to move towards opt-out testing for HIV in the UK.

    BMJ (Clinical research ed.)·2007
    Same author

    Aging-dependent changes in the effect of daily melatonin supplementation on rat metabolic and behavioral responses.

    Journal of pineal research·2001
    Same author

    Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo-pituitary-adrenal axis.

    Alcoholism, clinical and experimental research·2001
    Same author

    Women doctors in the movies.

    The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha·2000
    Same author

    Incidence and trends in Kaposi's sarcoma in the era of effective antiretroviral therapy.

    Journal of acquired immune deficiency syndromes (1999)·2000
    Same author

    Human herpesvirus 8 and Kaposi's sarcoma in persons infected with human immunodeficiency virus.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2000

    Area of Science:

    • Medical Microbiology
    • Immunology
    • Serological Diagnostics

    Background:

    • Syphilis serodiagnosis relies on accurate treponemal tests.
    • Comparing hemagglutination tests (MHA-TP, TPHA) with FTA-ABS is crucial for diagnostic utility.

    Purpose of the Study:

    • To evaluate the sensitivity and specificity of MHA-TP and TPHA compared to FTA-ABS for syphilis serodiagnosis.
    • To assess the reproducibility of the hemagglutination tests.

    Main Methods:

    • Comparative analysis of MHA-TP, TPHA, and FTA-ABS test results.
    • Testing sera from 935 non-syphilis patients and 68 syphilis patients.
    • Evaluation of test reproducibility and transient false-positive results.

    Main Results:

    • MHA-TP and FTA-ABS demonstrated high specificity (0.96% and 1.3% false positives, respectively).
    • MHA-TP sensitivity was comparable to FTA-ABS across syphilis stages, except untreated primary syphilis.
    • TPHA showed potential undersensitivity, with some false-negative results converting to positive over time.

    Conclusions:

    • MHA-TP is a valuable confirmatory test for syphilis serodiagnosis.
    • The TPHA test requires further investigation before clinical recommendation due to observed sensitivity issues.

    Related Experiment Videos